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Update in Asthma 2015

Operator Jurnal Artikel

Abstract - Our understanding of asthma has evolved over time from a singular disease to a complex of various phenotypes, with varied natural histories, physiologies, and responses to treatment as outlined in a conceptual overview by Gauthier and colleagues (1). Although most patients with asthma traditionally have been treated uniformly with bronchodilators and corticosteroids, these therapies admittedly had varying degrees of success, particularly in more severe disease. Similarly, despite initial studies that identified an underlying type 2.. [ Read More ]

Undiagnosed Chronic Obstructive Pulmonary Disease Contributes to the Burden of Health Care Use

Operator Jurnal Artikel

Abstract - Abstract Rationale: Chronic obstructive pulmonary disease (COPD) remains undiagnosed in many individuals with persistent airflow limitation. These individuals may be susceptible to exacerbation-like respiratory events that consume health care resources. Objectives: To compare exacerbation-like respiratory events, event prevalence, and differences in the odds of using medication and/or health services between subjects with diagnosed and undiagnosed COPD. Methods: Subjects sampled from the general population participating in the CanCOLD.. [ Read More ]

The Misapplication of Severity-of-Illness Scores toward Clinical Decision Making

Operator Jurnal Artikel

Abstract - Decision tools and severity-of-illness scores are two distinct entities with different derivation methodologies and applications. In real-world practice, however, decision tools and severity-ofillness scores are frequently used interchangeably, resulting in the misapplication of severity-of-illness scoring systems to inform clinical decision making. The Sepsis III clinical criteria for the assessment of sepsis (in particular, the quick Sequential Organ Failure Assessment [qSOFA] score) and associated recommendations, recently presented .. [ Read More ]

The Effect of Cigarette Smoking on Lung Function in Young Adults with Asthma

Operator Jurnal Artikel

Abstract - Abstract Rationale: Life-course persistent asthma and tobacco smoking are risk factors for irreversible airflow obstruction. It is often assumed that smoking and asthma have additive or multiplicative effects on the risk for airflow obstruction, but this has not been demonstrated in prospective studies of children with persistent asthma. Objectives: To investigate the effects of smoking and asthma on the development of airflow obstruction in a population-based birth cohort followed to age 38 years. Methods: Reports of childhood asthma .. [ Read More ]

Syndecan-1 Attenuates Lung Injury during Influenza Infection by Potentiating c-Met Signaling to Suppress Epithelial Apoptosis

Operator Jurnal Artikel

Abstract - Abstract Rationale: Syndecan-1 is a cell surface heparan sulfate proteoglycan primarily expressed in the lung epithelium. Because the influenza virus is tropic to the airway epithelium, we investigated the role of syndecan-1 in influenza infection. Objectives: To determine the mechanism by which syndecan-1 regulates the lung mucosal response to influenza infection. Methods: Wild-type (WT) and Sdc12/2 mice were infected with a H1N1 virus (PR8) as an experimental model of influenza infection. Human and murine airway epithelial cell cul.. [ Read More ]