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Premature Infants Rehospitalized because of an Apparent Life-Threatening Event Had Distinctive Autonomic Developmental Trajectories

Operator Jurnal Artikel

Abstract - Each year, 500,000 babies are born prematurely in the United States (1), and prematurity is now the largest single cause of death around the world in children before age 5 years (2). Premature infants have respiratory instability beyond term characterized by life-threatening episodes of apnea and hypoxemia that increase their morbidity and mortality risk (3, 4). Preterm birth interrupts the development and maturation of the autonomic nervous system (ANS), which regulates normal ventilatory drive and autoresuscitation responses during pe.. [ Read More ]

Pirfenidone for Idiopathic Pulmonary Fibrosis

Operator Jurnal Artikel

Abstract - Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease that typically leads to death within 5 years of diagnosis (2). The antifibrotic agent pirfenidone was recently approved for treatment of IPF. Pirfenidone was evaluated in two multinational phase 3 trials (CAPACITY [Clinical Studies Assessing Pirfenidone in Idiopathic Pulmonary Fibrosis: Research of Efficacy and Safety Outcomes]) with conflicting results, prompting a third phase 3 trial (ASCEND [Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pu.. [ Read More ]

Official American Thoracic Society Clinical Practice Guidelines: Diagnostic Evaluation of Infants with Recurrent or Persistent Wheezing

Operator Jurnal Artikel

Abstract - Background: Infantilewheezing is a common problem, but there are no guidelines for the evaluation of infants with recurrent or persistent wheezing that is not relieved or prevented by standard therapies. Methods: An American Thoracic Society–sanctioned guideline development committee selected clinical questions related to uncertainties or controversies in the diagnostic evaluation of wheezing infants. Members of the committee conducted pragmatic evidence syntheses, which followed the Grading of Recommendations, Assessment, Development.. [ Read More ]

Myeloid Targets for Pulmonary Arterial Hypertension: Time for Another Look

Operator Jurnal Artikel

Abstract - We commend Yan and colleagues (1) on their elegant studies, which add to the accumulating evidence of a myeloid/bone marrow origin of pulmonary arterial hypertension (PAH). Using reciprocal bone marrow chimeras in immunocompetent Bmpr2 mutant and wild-type mouse models, the authors identify bone marrow–dependent mechanisms in the muscularization of pulmonary arterioles and right ventricular systolic pressure elevation, without right ventricular hypertrophy. The findings are complementary to our previous xenograft study (2), in which h.. [ Read More ]

Lung Transplant and Extracorporeal Membrane Oxygenation

Operator Jurnal Artikel

Abstract - Extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplant has become a lifesaving intervention for a subset of rapidly deteriorating patients with end-stage lung disease. Overall, ECMO use has grown exponentially since the CESAR (Conventional Ventilatory Support versus Extracorporeal Membrane Oxygenation for Severe Adult Respiratory Failure) trial and experience during the 2009 influenza A(H1N1) outbreak (1, 2). Importantly, increasing experience and successful reports of ambulatory, awake ECMO have resulted in widesprea.. [ Read More ]