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Loud and Clear: Sensory Impairment, Delirium, and Functional Recovery in Critical Illness

Operator Jurnal Artikel

Abstract - Numerous landmark studies confirm the profound impact that critical illness and intensive care have on the long-term health of patients and their families (1, 2). This so-called “post–intensive care syndrome” manifests itself through increased risks of mortality and disability after discharge as well as through neuropsychiatric sequelae afflicting patients and caregivers alike (2, 3). As our population ages, the toll of critical illness on the most vulnerable—elderly patients who consume a growing proportion of intensive care un.. [ Read More ]

Living with a Tracheostomy

Operator Jurnal Artikel

Abstract - Some patients with a tracheostomy are able to go home. One major factor in moving back home is whether you still need a breathing machine (ventilator) to help you breathe. Other factors include whether you or your caregiver(s) are able to take care of your needs and how healthy you are. ?? If you required a trach for an injury or blockage of your windpipe and your health is otherwise good enough, you may be able to go home directly from the hospital. ?? If your trach was placed because you could not breathe well enough on your own with.. [ Read More ]

Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis

Operator Jurnal Artikel

Abstract - Abstract Rationale: The development of host-targeted, prophylactic, and therapeutic interventions against tuberculosis requires a better understanding of the immune mechanisms that determine the outcome of infection with Mycobacterium tuberculosis. Objectives: To identify T-cell–dependent mechanisms that are protective in tuberculosis. Methods: Multicolor flow cytometry, cell sorting and growth inhibition assays were employed to compare the frequency, phenotype and function of T lymphocytes from bronchoalveolar lavage or the periphe.. [ Read More ]

Hypothermia and Meconium Aspiration Syndrome: International Multicenter Retrospective Cohort Study

Operator Jurnal Artikel

Abstract - Whole-body hypothermia (WBH) is the cornerstone treatment of neonatal hypoxic-ischemic encephalopathy (HIE) resulting from perinatal asphyxia (1). HIE might occur with meconium aspiration syndrome (MAS), which is characterized by surfactant dysfunction and lung inflammation (2). Animal and translational studies suggest that “lung cooling” could have beneficial effects, reducing lung inflammation and improving surfactant function (3, 4). Recent case reports of an infant and an adult patient with acute respiratory distress syndrome al.. [ Read More ]

Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors

Operator Jurnal Artikel

Abstract - Abstract Rationale: Most of the 1.4 million older adults who survive the intensive care unit (ICU) annually in the United States face increased disability, but little is known about those who achieve functional recovery. Objectives: Our objectives were twofold: to evaluate the incidence and time to recovery of premorbid function within 6 months of a critical illness and to identify independent predictors of functional recovery among older ICU survivors. Methods: Potential participants included 754 persons aged 70 years or older who we.. [ Read More ]